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butabarbital will reduce the extent or result of zonisamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unfamiliar.butabarbital raises consequences of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use Caution/Watch. Coadministration of ifosfamide with CYP2B6 inducers might boost metabolism of ifosfamide to